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What is Senolytic complex, with its cellular senescence and it's relationship to a healthy aging process? Sickness, damage to bodily tissues, and other traumatic factors harm cells within our bodies. Ideally, the damaged cells are cleared by our immune systems through a process called apoptosis. But as we age, our bodies are no longer as effective at removing dysfunctional cells, and this can contribute to a weakened immune system and other less efficient biological processes. A growing number of researchers are exploring whether learning to harness a cellular state known as senescence — during which damaged cells resist removal by apoptosis, linger, and cause damage to the normal neighboring cells - might hold the key to revitalizing aging tissues and increasing healthy, active years of life. What is cellular senescence? Senescent cells are special in that they eventually cease multiplying but don’t die off when they should. They instead remain and continue to release harmful chemicals that can trigger inflammation. Like the one moldy piece of fruit that spoils the entire bowl, a relatively small number of senescent cells can persist and spread inflammation that can damage neighboring cells. However, not all senescent cells are bad. The molecules and compounds expressed by senescent cells (known as the senescent secretome) play important roles across the lifespan, including in embryonic development, childbirth, and wound healing. What exactly are senolytics? Senolytics is a phrase used to describe any senolytic compounds (drugs, plant extracts, or peptides) or cell-clearing remedial therapies that work to get rid of senescent cells from the body. Examples of senolytics include theaflavins (derived from black tea), dasatinib, and quercetin (a flavanol found in many plants). What makes senolytics tick? In 2014, researchers achieved a major accomplishment in the fight against aging. They identified old, worn-out cells in the tissues of subjects aged over 40. Termed “senescent cells,” these zombie-like cells are deformed and unable to divide and are distributed throughout the body’s tissues. Even though they’re no longer operating normally, they’re also not cast aside and as a consequence accumulate pathologically. The proliferation of these cells are seldom seen in young people but the odds of them developing increases with age, particularly in adipose tissue, skeletal muscle, blood vessels, the brain, kidneys and skin. How they affect healthy cells: Unfortunately, senescent cells do not just take over, they also impede the activity of neighboring healthy cells by continually releasing pro-inflammatory cytokines (IL-1, IL-6 and IL-8), vesicles and insoluble proteins (fibronectin, collagen) into the extracellular environment. These substances are really distress calls: they signal to other cells the advanced state of deterioration in which they find themselves, but at the same time, they significantly affect the function of neighboring healthy cells. Over the last three years, a number of studies have shown that the level of senescent cells in the body is directly linked to the pace of aging, when the risk of developing age-related health problems is higher. Combating senescent cells: These cells normally destroy themselves in a process called apoptosis in order to avoid damaging the body. However, this mechanism does not always work, in which case the senescent cells continue to parasitize the body and potentially cause harm. Fortunately, researchers have identified several compounds that aid the repair of this defective mechanism, potentially bringing about the self-destruction of these senescent cells. These extraordinary compounds are called senolytics. The first study to identify senolytics was published in 2015. Quercetin, a natural flavonoid compound, was found to dramatically decrease both the number of senescent cells and secretion of pro-inflammatory factors in the organism studied. Dozens of studies have since identified natural compounds with the same properties. This has led to the development of a revolutionary new therapy, senolytic therapy, which is able to selectively destroy senescent cells and potentially reduce the severity of age-related health problems and increase the body’s resilience and longevity. And those are just some of the quercetin phytosome benefits. Senolytic therapy is essentially a massive spring cleaning, after which healthy cells regain control of the body and again function at full capacity. It represents a significant advance in the fight against aging. What is in Senolytic Complex? Senolytic Complex contains three exceptional senolytic compounds (fisetin, quercetin and theaflavin) and three other anti-aging compounds (Vitamin C, nicotinamide mononucleotide and bromelain). Fisetin: Fisetin is part of the large family of flavonoids, a group of polyphenol antioxidants found in small amounts in strawberries, mangos and certain types of plants. Of all the flavonoids that have been tested, it has shown to be the most effective at reducing the number of senescent cells. Its hydrophobic nature means it penetrates cells easily via cell membranes and subsequently promotes the self-destruction of abnormal cells (such as senescent cells) by activating specific proteins. One of its abilities includes reducing the fraction of senescent cells in the immune system (T lymphocytes and NK cells), which increases its beneficial effects since immune cells are also important for clearing out senescent cells. In addition, it inhibits the activity of several inflammatory cytokines such as TNFα, IL-6, and the transcription factor NF-Κb, and it may even help lower fat levels in the blood. Quercetin and Theaflavin: Since senescent cells use different mechanisms to resist programmed cell death, it’s important that other senolytic compounds are included in the formulation. In our senolytic supplement formula, quercetin phytosome and theaflavin are those two senolytic compounds. Quercetin, like fisetin, is a member of the flavonoid family. The Quercefit in Senolytic Complex is extracted from Styphnolobium japonicum, the Japanese pagoda tree or “honey tree.” So what is quercetin phytosome? It’s essentially quercetin delivered in a phytosome form which maximizes its absorption into the bloodstream. In fact, a comparison of quercetin phytosome vs quercetin shows that quercetin phytosome is 20 times more bioavailable than standard quercetin. But what is quercetin phytosome used for? In combination with theaflavin, a polyphenol from black tea, these benchmark senolytic are also designed to destroy senescent cells, just like Fisetin. Our formulation contains the most powerful, natural, senolytic compounds identified to date: quercetin phytosome, theaflavin, and most importantly, fisetin, an extraordinary flavonoid that’s gaining recognition in the scientific community. Bromelain, NMN and Vitamin C: Our senolytic supplement is enhanced by the addition of anti-aging substances that work in symbioses, such as nicotinamide mononucleotide, an element essential for cellular energy production and longevity of sirtuin proteins, bromelain, an enzyme which actively opposes systemic inflammation, and Vitamin C (in its non-acid form), a potent antioxidant that supports the immune system. Quercetin Phytosome Side Effects - Now that you understand the difference between quercetin vs quercetin phytosome, you are ready to use senolytic supplements for optimal well-being. But, before you take a senolytic supplement, you need to know more than fisetin or quercetin phytosome’s uses; you also need to know potential side effects. For most people, it is completely safe to take quercetin phytosome supplements. However, you may be taking a medication or have a health condition that could interact with them. That’s why you should always discuss new supplement regimens with your healthcare provider. If you begin taking a new supplement and notice any side effects, stop using immediately and speak with your practitioner. Additionally, pregnant women and nursing mothers should use extra caution when taking supplements. Until more research is performed, it’s best to avoid any new substances that you don’t need to take. And please note that fisetin senolytic supplements should not be taken in conjunction with antivitamin K drugs, which are commonly used oral anticoagulants. Some of the benefits of Senolytic Complex: (1). Senolytic Complex is designed to destroy the senescent cells responsible for aging. (2). Has a rapid and long-lasting rejuvenating effect on the whole body. (3). Encourages self-destruction of the senescent cells responsible for aging and age-related health issues (muscle weakness, cognitive decline, cardiovascular problems, chronic inflammation, etc.) (4). Rich in fisetin, one of the most powerful natural senolytic compounds and contains quercetin phytosome, which is 20 times more absorbable than standard quercetin. Who should consider taking Senolytic Complex? Generally, Senolytic Complex is made for anyone over the age of 40, looking for a way to combat the creation of senescent cells. It is particularly recommended for anyone looking to maintain good physical condition and optimal health as they age, as well as anyone who’s already experiencing age-related problems, including muscle and joint weakness, heart problems, vision and hearing impairments, cognitive decline, as well as anyone who’s interested in reducing their risk of developing them. To learn more click here.