How To Lose Weight Fast With A Phentermine-Topiramate Pill What is the best FDA-approved weight loss pill? Phentermine-Topiramate pill  (Qsymia) is the best, most effective, weight loss drug available to date. 50,52, It combines an adrenergic agonist with a neurostabilizer. Daily doses with four strengths start at 3.75/23mg to 15mg/92mg. Adults with migraines and obesity are good candidates for this weight loss medication. Why A Phentermine-Topiramate Pill? A Phentermine-Topiramate pill extended-release (long-acting) or capsules are used to help adults who are obese or who are overweight and have weight-related medical issues to lose weight and to prevent them from gaining the weight back. A Phentermine- topiramate pill must be used along with a reduced calorie diet and exercise plan. Phentermine is in a class of medications called anorectics. It works by decreasing appetite. Topiramate is in a class of medications called anticonvulsants. It main purpose is to act as an appetite suppressant and cause feelings of satiety after eating. How Does This Prescription Medicine Work? A Phentermine-topiramate pill  (Qsymia) come as extended-release capsules to take by mouth. The medication is usually taken with or without food once a day in the morning. This medication may cause difficulty falling asleep or staying asleep if it is taken in the evening. Take a phentermine-topiramate pill at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take the phentermine-topiramate pill precisely as directed. Usually Started On A Low Dose Your doctor will probably start you on a low dose of phentermine and topiramate and up your dose after 14 days. After the initial 12 weeks, your doctor will check to see how much weight you have lost. If you have not lost a certain amount of weight, your doctor might take you off of the phentermine and topiramate or may increase your dose and then increase it again after 14 days. After you take the new dose for 12 weeks, your doctor will check to see how much weight you have lost. If you have not lost a certain amount of weight, it is not likely that you will benefit from taking phentermine and topiramate, so your doctor will probably tell you to stop taking the medication. Scientifically Backed Weight Loss According to a pooled analysis of several placebo-controlled randomized controlled trials lasting 2 to 24 weeks, patients that were treated with phentermine had a 3.6 kg greater weight loss 22,when compared to the placebo group.22 The authors of this analysis determined that the addition of phentermine to lifestyle modifications did result in a statistically significant increase in weight loss. One of the longest studies conducted using phentermine was published in 1968.57 One-hundred-eight obese women were randomly assigned to receive placebo, continuous phentermine daily, or intermittent phentermine (4 weeks on therapy and 4 weeks off of therapy) for 36 weeks. All of these patients were instructed to continue on a 1000 calorie/day diet but were not given any further instruction regarding lifestyle changes. Sixty-four patients completed the trial with an average weight loss of 10.5 pounds for the placebo group, 27 pounds for the continuous phentermine group, and 28.7 pounds for the intermittent phentermine group. These results demonstrated that intermittent therapy may be as effective as daily phentermine treatment. It's worth mentioning, the patients receiving intermittent therapy experienced some weight regain or experienced even more weight loss. What Are some Of The Proven Benefits With Phentermine-Topiramate Pill? Qsymia is a prescription medicine that contains a phentermine-topiramate pill extended-release that may help some obese adults or some overweight adults who also have weight-related medical problems lose weight and keep the weight off. Qsymia should be used in conjunction with a reduced calorie diet and increased physical activity. Weight Loss Numbers - The mean weight loss achieved for the maximum dose combination was 9.21% compared to 6.06% in the max dose phentermine alone and 6.44% in the max dose topiramate alone groups and these findings were statistically significant. The 7.5/46 mg group was associated with ~8.46% weight loss from baseline. How quickly do people lose weight on Qsymia? My results have been good. I lost 25 pounds in the first 3 weeks - two weeks on the 3.5mg and one week on the 7mg. Takeaway The Phentermine and topiramate  combination (Qsymia) is the best prescription weight loss pill to help you control your weight only as long as you continue to take the medication. Do not stop taking phentermine and topiramate without talking to your doctor. If for some reason you suddenly stop taking phentermine and topiramate, you may experience seizures. Your doctor will tell you how to decrease your dose gradually. Phentermine and topiramate may be habit forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor. Phentermine and topiramate is now available at retail pharmacies. This medication is available only through specific mail order pharmacies. Ask your doctor if you have any questions about how you will receive your medication. Learn more. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with phentermine and topiramate and each time you refill your prescription. Learn more.